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5° NPCF Nuove Prospettive in Chimica Farmaceutica > Programma del Convegno  

Programma del Convegno

V NPCF Nuove Prospettive in Chimica Farmaceutica

 

28 marzo 2011

 

14.00-17.00       Iscrizione

17.00-18.30       Saluti delle Autorità

Sala Tergeste

 

18.30-19.30       Plenary lecture: Wandering around new targets. Opportunities and risks for medicinal chemistry research Gabriele Costantino (Università di Parma)

20.00                 Cocktail di benvenuto

 

29 marzo 2011

 

Sala Tergeste

                          RECEPTORS

 

09.00-09.40       Main lecture: Receptor insight: recent advances in the development of novel therapeutic agentsClaudia Martini (Università di Pisa)

                          Short communications. Chairman: Claudia Martini

09.40-10.00       A novel series of potent calcium-sensing receptor antagonists for the treatment of osteoporosis – Luca Arista (Novartis)

10.00-10.20       D2 dopamine receptor agonists as allosteric modulators of A2a adenosine receptor signalling - Simona Daniele (Università di Pisa)

10.20-10.40       1,2,4-Triazolo[1,5-a]-1,3,5-triazine nucleus: a possible template for adenosine receptor subtypes – Stephanie Federico (Università di Trieste)

10.40-11.00       Pyrrole-based selective COX-2 inhibiting nitric oxide donors: synthesis, in vitro and in vivo evaluation – Claudio Battilocchio ("Sapienza" Università di Roma)

 

11.00-11.20       Coffee break

 

11.20-11.40       Exploration of multivalency in 5-HT3 receptor – Marco Paolino (Università di Siena)

11.40-12.00       Anthranilic acid based CCK1 receptor antagonists – Michela Pavan (Università di Trieste)

12.00-12.20       Overview on σ1 receptors: a 3D homology model to solve a part of the enigma – Erik Laurini (Università di Trieste)

12.20-12.40       Selective GluK1 Receptor Ligands Structurally Based upon (S)-CPW399: Synthesis, Pharmacological, and Biostructural Characterization – Samuele Maramai (Università di Siena)

12.40-13.00       CB2 selective agonists as neuroprotective agents – Serena Pasquini (Università di Siena)

 

Sala Zodiaco

                          Analytical Pharmaceutical Sciences

 

09.00-09.40       Main lecture: The role of chirality in drug discovery and developmentCarlo Bertucci (Università di Bologna)               

                          Short communications. Chairman: Carlo Bertucci

09.40-10.00       Covalent modification of b2-microglobulin induced by reactive carbonyl species: high resolution mass spectrometric studies – Laura Bertoletti (Università di Pavia)

10.00-10.20       New potential antimalarials based on the 4-aminoquinoline scaffold – Caterina Camodeca (Università di Siena)

10.20-10.40       Capillary electrophoresis: an analytical strategy to evaluate the effects of small molecules on the toxic aggregates of Alzheimer’s disease – Raffaella Colombo (Università di Pavia)

10.40-11.00       Concentrations of HPLC-samples: current methods and future trends – Jürgen Grebe (Martin Christ)

 

11.00-11.20       Coffee break

 

11.20-11.40       Synthesis of novel endoperoxide derivatives as potential antimalarial agents – Sanil Kunjir (Università di Siena)

11.40-12.00       Latest innovations in vacuum technology and control – Carsten Ruth (Vacuubrand)

12.00-12.20       Mechanistic investigations on a ligand-exchange system operating with a chiral mobile phase – Roccaldo Sardella (Università di Pavia)

12.20-12.40       Stereochemistry of 2-(6-fluorophenanthren-1-yl)propionic acid unveiled by enantioselective HPLC, ECD spectroscopy, and TD-DFT calculations – Daniele Tedesco (Università di Bologna)

12.40-13.00       CNT-based electrochemiluminescent biosensor for palytoxin detection – Valeria Zamolo (Università di Trieste)

  

13.00                 Pranzo

 

Sala San Giusto

14.00                 Sessione poster

 

Sala Tergeste

                          Oncology

 

15.00-15.40       Main lecture: Development of novel drugs for the treatment of colorectal cancer: focus on recently identified and potential molecular targetsEnrico Mini (Università di Firenze)

                          Short communications. Chairman: Enrico Mini

15.40-16.00       Non-natural macrocyclic inhibitors of histone deacetylases – Gianfranco Battistuzzi (Sigma-Tau)

16.00-16.20       Ligand-receptor interactions from NMR spectroscopy. Application to cytotoxic agents binding to DNA – Diego Brancaccio (Università di Napoli)

16.20-16.40       Synthesis and biological evaluation of a new thiazole derivative, inducing histone hypoacetylation and apoptosis in human leukemia cells – Simone Carradori (“Sapienza” Università di Roma)

16.40-17.00       Covalent antibody-carbon nanotubes conjugates for improved anticancer therapy – Chiara Fabbro (Università di Trieste)

 

17.00-17.20       Coffee break

 

17.20-17.40       Structure-activity relationships of new anticancer agents based on naphthalene diimide scaffold – Andrea Milelli (Università di Bologna)

17.40-18.00       Structure-actvity relationship study of new FK228 analogues as antitumor agents – Salvatore Di Maro (Università di Napoli)

18.00-18.20       Ruthenium-porphyrin conjugates with cytotoxic and phototoxic antitumor activity – Cinzia Spagnul (Università di Trieste)

18.20-18.40       Targeting tyrosine kinases: anti-proliferative and anti-angiogenic properties of 4-anilinoquinazolines – Francesca Tonus (Università di Padova)

18.40-19.00       Synthesis and evaluation of 3-methyl-4-oxo-1,5,6,7-tetrahydroindole-2-carboxylic acid ester derivatives as potential anticancer agents – Paolo Trifirò (Istituto Europeo di Oncologia)

19.00-19.20       Isoxazolo[5,4-e]isoindole a new ring system with potent antitumor activity – Virginia Spanò (Università di Palermo)

 

Sala Zodiaco

                          COMPUTER AIDED DESIGN

 

15.00-15.40       Main lecture: Protein-ligand binding free energy and kinetics – Andrea Cavalli (Università di Bologna)

                          Short communications. Chairman: Andrea Cavalli

15.40-16.00       A new weapon in the fight against HIV. Discovery and synthesis of new inhibitors of the human RNA helicase DDX3 – Gianni Casaluce (Università di Siena)

16.00-16.20       Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization – Antonio Coluccia (Università di Siena)

16.20-16.40       The role of N-terminal domain in the regulation of “constitutively active” conformation of protein kinase CK2α: new insights from a molecular dynamics investigation – Andrea Cristiani

                           (Università di Ginevra) 

16.40-17.00       SERAPhiC: an ideal benchmark for in silico fragment-based drug design – Angelo Favia (Istituto Italiano di Tecnologia)

 

17.00-17.20       Coffee break

 

17.20-17.40       Swimming into peptidomimetic chemical space using  pepMMsMIMIC – Matteo Floris (CRS4)

17.40-18.00       Computer-aided drug discovery of p-tefB inhibitors as anti-hiv agents – Nunzio Iraci (Università di Perugia)

18.00-18.20       Structure-Based Design of EGFR Covalent Inhibitors – Alessio Lodola (Università di Parma)

18.20-18.40       Rational drug design of dna g-quadruplex binders using structure-based computational approaches – Federica Moraca (Università Magna Græcia)

18.40-19.00       From computer to in vivo: computational/experimental evidences for designing efficient nanovectors for gene therapy – Paola Posocco (Università di Trieste)

 

20.30                 Cena di gala

30 marzo 2011

 

Sala Tergeste

 

08.45-09.45       Plenary lecture: Biomaterials and NanomedicineMaurizio Prato (Università di Trieste)

 

 

Sala Tergeste

                          NEURODEGENERATIVE DISEASES

 

09.50-10.30       Main lecture: Targeting CNS: opportunities and challenges for medicinal chemistry – Fabrizio Micheli (Aptuit  Verona)

 

10.30-10.50       Coffee break

                         

                          Short communications. Chairman: Fabrizio Micheli

10.50-11.10       Synthesis and biological evaluation of multi-target directed ligands against prion diseases – Salvatore Bongarzone (SISSA)

11.10-11.30       In silico exploration of the embryonic lethal abnormal vision protein-mRNA interaction followed by in vitro bioassays for the identification of peptides potentially useful in neurodegenerative diseases

                          treatment – Anna Carnevale Baraglia (Università di Pavia)

11.30-11.50       A small focused chemical library of 2-aminoimidazole derivatives as bace-1 inhibitors – Gianpaolo Chiriano (SISSA)

11.50-12.10       Successful optimization of human carbonic anhydrase inhibitors as neuroprotective agents – Francesca Maria Damiano (Università di Messina)

12.10-12.30       Aminothienopyridazine inhibitors of tau aggregation – Francesco Piscitelli (Università di Roma)

12.30-12.50       New Leads for the Inhibition of Monoammino-Oxidase B – Maria Luisa Sanna (Università di Cagliari)

 

 

Sala Zodiaco

                          Protein-Protein Interactions

 

09.50-10.30    Main lecture: Protein-protein interactions modulation for therapeutic intervention  Alessandro Padova (Siena Biotech)

 

10.30-10.50    Coffee break

 

                          Short communications. Chairman: Alessandro Padova

10.50-11.10       Protein-protein interaction disruptors. Design and synthesis of thienylpyridyl oligomers as non-peptidic alpha helix mimetics – Marcella De Giorgi (Università di Bari)

11.10-11.30       Targeting protein-protein interactions: a promising anti-HIV drug discovery strategy – Laura De Luca (Università di Messina)

11.30-11.50       Molecular dynamics as tool to investigate conformational transitions of MDM2 in response to ligand binding – Nicola Giacchè (Università di Perugia)

11.50-12.10       Chemical genetics approach to drug discovery by Diversity-Oriented Synthesis (DOS) of peptidomimetics – Andrea Trabocchi (Università di Firenze)

12.10-12.30       Structural conformational analysis of e-cadherin germline missense mutations in two sporadic gastric cancer patients – Marica Garziera (Centro di Riferimento Oncologico Aviano)

12.30-12.50       From single- to multi-target tyrosine kinases inhibitors: using the "old-age" kinases inihibitors data to face the "new-age" – Giovanni Marzaro (Università di Padova)

 

 

Sala Tergeste

12.50-13.15       Chiusura dei lavori

13.15                 Pranzo